Gynecology and obstetrics specialist Dr. Çağlar Yazıcıoğlu, who noted that in vitro fertilization is the most effective method of treatment in infertility today, said: “If the factors leading to recurrent IVF failures are determined and the right methods are applied, the chances of conceiving children are greatly increased . It is critical to determine whether the problem is caused by the egg, sperm, uterus or fallopian tubes, and to start treatment by preparing a new treatment. Gynecology and obstetrics specialist Dr. Çağlar Yazıcıoğlu explained the factors that increase the success of IVF treatment and made important suggestions.
Do not delay treatment
The most important factor determining the success of IVF treatment is the woman’s age. Because while women’s reproductive capacity is at its highest between the ages of 20 and 40, it declines rapidly after age 40. Therefore, not delaying the IVF method plays a key role in the success of the treatment.
Note the egg reserve
The number of eggs is the second most important factor after the age of the woman that determines the success of the treatment. In women with good ovarian reserve, the number of eggs in each ovary is normally expected to be about 7-8. When the egg count is low, the level of the anti-mullerian hormone decreases. Dr Çağlar Yazıcıoğlu said: “When ovarian reserve is low, expectant mothers should apply for IVF treatment even at a young age. It is also beneficial for expectant mothers who need to postpone their baby plan to freeze embryos or eggs.
Selecting quality eggs and sperm
Developing quality eggs, choosing quality sperm, creating quality embryos and a well-executed transfer are the main factors that ensure a high conception rate. Because thanks to high-quality embryos, the chance of pregnancy increases rapidly.
Uterine film (HSG) is important
Fluid in the fallopian tubes (hydrosalpinx) or intrauterine problems such as polyps and drapes can prevent pregnancy or cause a miscarriage, even if the embryo is of good quality. Properly taken uterine film is of great importance in detecting these problems.
Watch out for diseases of the reproductive organs!
In IVF treatment, if there is fluid in the tubes before the embryo transfer, the tubes are closed with laparoscopy to prevent fluid from flowing into the uterus. Problems such as polyps, drapes, and uterine adhesions may require hysteroscopy (an endoscopic incision-free surgery performed with a camera by entering the vagina), taking care not to damage intrauterine tissue.
perform genetic analysis
Another important reason for repeated IVF attempts can be genetic abnormalities that are seen in husbands, but not asymptomatic. If necessary, biopsies are taken from the embryos. The healthy chromosomes are determined from the embryos that are frozen one by one and the uterus is prepared. The genetically healthy embryo is then thawed and replaced.
Inflammation in the body, known as community inflammation, is another major factor that reduces the chances of success in IVF treatment. Inflammation is the body’s defense response to protect itself against microbial or non-microbial toxic factors. However, when inflammation continues continuously, it damages the body through tissue edema and inflammatory response. The reproductive cells in men and women are also seriously affected. The result is reflected in the quality of the embryo. Therefore, inflammation must be treated to achieve high success in IVF.
Develop healthy lifestyle habits
Factors such as obesity, smoking and poor quality sleep can also hinder the success of IVF treatment. Therefore, it is possible for couples to quit smoking, lose their excess weight by eating healthy, exercising regularly, providing sleep hygiene and reducing inflammation in the body with antioxidant support, improving the quality of sperm and eggs. In this way, a qualitative embryo development and the chance of pregnancy can increase significantly.
If there is sperm DNA damage!
In men, factors such as excessive smoking, exposure to high temperatures, chemicals in the environment, medications used for certain diseases, chemotherapy, and radiotherapy can cause DNA damage in the sperm. To increase the success of IVF treatment, giving up smoking in the presence of high sperm DNA damage, reducing body fat, treating any infections, using antioxidants and ensuring hormonal regulation can improve the quality of significantly increase the embryo and the success of the treatment.
to treat infections
Some asymptomatic reproductive infections such as trichomonas and ureaplasma also negatively affect sperm quality. Gynecology and obstetrics specialist Dr. “Detecting these factors with a PCR test on the genital panel and removing them before treatment is important for the development of quality sperm and embryos, especially in couples with failed attempts,” says Çağlar Yazıcıoğlu.