Patients can be treated without the use of antibiotics









Recep Tayyip Erdogan University Faculty of Arts and Sciences Department of Biology Lecturer Prof. dr. Dr. Şengül Alpay Karaoğlu developed an alternative antibiotic treatment method against the causative agent of throat infection with the project called “Characterization of Streptococcus pyogenes bacteriophages and determination of bacteriolytic activities of endolysin protein”. The study, supported by the Presidency of Turkish Institutes of Health (TÜSEB), will enable the development of products such as sprays or disinfectants without antibiotics in throat infections, using bacterial viruses, to permanently treat throat infections. Karaoğlu said that phages specific to streptococcal infection will be characterized for the first time in Turkey and brought to world literature.

Patients can be treated without the use of antibiotics

prof. Dr Şengül Alpay Karaoğlu said: “In order for this study not to stop here and go further, we naturally wanted to isolate bacterial viruses and in some cases phage isolation, which can be an alternative to antibiotics in a way, and we presented a project at the Turkish Institute of Health Sciences in this field. The project we gave to TUSEBE was the isolation of group A beta-hemolytic streptococcal (GAS) phages and studies of the enzyme activity of the phage gene homo. If this study can be successfully completed, our goal here is to create a phage culture collection with similar studies. To activate the phage-related therapy method for antibiotics, especially in superficial infections.”

“An alternative solution in areas where antibiotics are not sufficient is phage therapy”

Karaoğlu stated that alternative solutions would be used in areas where antibiotics were not sufficient, saying: “In fact, phage therapy was practiced in Russia from 1940 to 1975-1985 in the years before the discovery of antibiotics in the world and their development. However, these studies are limited by the introduction of antibiotics into our lives. Although antibiotics have been discovered, they are facing the development of resistance. We lose about 5 percent of our patients, as well as around the world, to lower respiratory infections. Phage therapy is a method that can be an alternative to this. We designed this project to initiate studies on this method. However, it will be the first study on streptococci in our country. After completing this research, we started by asking if we could have an alternative for children who might be allergic to medicines, especially for throat infections. I hope we will achieve positive results. Sure, we have phage isolates, but we’re aiming to make it usable with work as soon as possible, and get it into the application phase in larger projects in the later stages. Especially in cases where we cannot use antibiotics, an alternative solution is phage therapy in areas where antibiotics are not sufficient.”

Patients can be treated without the use of antibiotics


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