Symptoms of polycystic ovarian syndrome in women

exp. Dr. Çınkır stated that the syndrome is characterized by an excess of male hormones and irregular menstruation in women, underlining that this condition is a complex condition that is common in society.

Giving detailed information about the syndrome, Dr. Dr. Ümit Çınkır, “Although the causes of polycystic ovary syndrome are not known with certainty, the disease can occur through the interaction of genetic and environmental factors. The factors effective in the onset of polycystic ovarian syndrome are usually changes in the dynamics of hormones (gonadotropin) that regulate ovarian functions, steroidogenesis deficiencies, insulin secretion and dysfunction, along with genetic factors.

In patients with polycystic ovary syndrome, increased insulin resistance and obesity are common findings. In this picture, insulin resistance and high levels of insulin in the blood (hyperinsulinemia) increase androgen synthesis in the ovary, as well as a decrease in the level of sex hormone binding globulin, which increases the level of free testosterone. Androgen excess (hyperandrogenism) in patients may be biochemical or clinical.

Due to the increase in serum androgens, especially testosterone, in biochemical hyperandrogenism, an increase in hair growth (hirsutism) is observed in our patients. Acne, skin lubrication, and male pattern hair loss can also occur due to hyperandrogenism. In the menstrual histories of our patients with polycystic ovary syndrome, it is very noticeable that menstrual intervals are shorter than 21 days or longer than 35 days. However, it has been reported that up to twenty percent of people with polycystic ovarian syndrome may have regular menstrual cycles. Glucose intolerance, type 2 diabetes, dyslipidaemia, obesity, hypertension, cardiovascular disease and depression may also occur in these patients in the long term. In this sense, treatment goals can be stated as controlling the androgen excess, correcting menstrual irregularities and providing fertility.

Pharmacological approaches in the treatment of hyperandrogenism are suppression of androgens and reduction of target organ effects. Response to treatment occurs at the earliest at the end of six months. During this period care must be taken that the patients do not lose motivation. For successful treatment, pharmacological means must be used together with mechanical and cosmetic methods. If patients have insulin resistance, medical treatment options should be evaluated on a patient basis, in addition to lifestyle changes. In addition, since this disease can cause other health problems in the long term, close follow-up and treatment of this disease should be planned.

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